SCREENING OF PIROXICAM SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) USING FRACTIONAL FACTORIAL DESIGN

Piroxicam belongs to BCS class II and has low solubility. Self-nanoemulsifying drug delivery systems (SNEDDS) are considered a potential approach for increasing the solubility release of piroxicam. This study aimed select components component ratios piroxicam SNEDDS using fractional factorial design 26-2 (FFD). The variables used in DFT development type concentration oil (triacetin oleic acid), surfactant (kolliphor EL Tween 60), co-surfactants (Transcutol PEG 400). FFD results showed 16 runs with different proportions components, which were then characterized by critical parameters including emulsification time, %transmittance, droplet size, loading. PKM determined single-factor plot analysis. that triacetin (oil), kolliphor (surfactant), Transcutol (co-surfactant) had greatest contribution formation an ratio range 11.11–28.57%, 44.44–77.78%, co-surfactant 11.11–44.44 %.